A Computational Understanding of Inter-Individual Variability in CYP2D6 Activity to Investigate the Impact of Missense Mutations on Ochratoxin A Metabolism

A Computational Understanding of Inter-Individual Variability in CYP2D6 Activity to Investigate the Impact of Missense Mutations on Ochratoxin A Metabolism

Cytochrome P-450 (CYP) enzymes have a key role in the metabolism of xenobiotics of food origin, and their highly polymorphic nature concurs with the diverse inter-individual variability in the toxicokinetics (TK) and toxicodynamics (TD) of food chemicals. Ochratoxin A is a well-known mycotoxin which...

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Bibliographic Details
Main Authors: Jean Lou C. M. Dorne, Martina Cirlini, Jochem Louisse, Lorenzo Pedroni, Gianni Galaverna, Luca Dellafiora
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Toxins
Subjects:
ochratoxin A
CYP2D6
polymorphism metabolism
toxicokinetics
food safety
hazard assessment
Online Access:https://www.mdpi.com/2072-6651/14/3/207

Internet

https://www.mdpi.com/2072-6651/14/3/207

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