Potential role of B- and NK-cells in the pathogenesis of pediatric aplastic anemia through deep phenotyping

IntroductionPediatric patients with unexplained bone marrow failure (BMF) are often categorized as aplastic anemia (AA). Based on the accepted hypothesis of an auto-immune mechanism underlying AA, immune suppressive therapy (IST) might be effective. However, due to the lack of diagnostic tools to id...

Full description

Bibliographic Details
Main Authors: Lotte T. W. Vissers, Monique M. van Ostaijen-ten Dam, Janine E. Melsen, Yanna M. van der Spek, Koen P. Kemna, Arjan C. Lankester, Mirjam van der Burg, Alexander B. Mohseny
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1328175/full