The Impact of Serum Protein Adsorption on PEGylated NT3–BDNF Nanoparticles—Distribution, Protein Release, and Cytotoxicity in a Human Retinal Pigmented Epithelial Cell Model

The Impact of Serum Protein Adsorption on PEGylated NT3–BDNF Nanoparticles—Distribution, Protein Release, and Cytotoxicity in a Human Retinal Pigmented Epithelial Cell Model

The adsorption of biomolecules on nanoparticles’ surface ultimately depends on the intermolecular forces, which dictate the mutual interaction transforming their physical, chemical, and biological characteristics. Therefore, a better understanding of the adsorption of serum proteins and their impact...

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Bibliographic Details
Main Authors: Maria Dąbkowska, Alicja Kosiorowska, Bogusław Machaliński
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
brain-derived neurotrophic factor (BDNF)
neurotrophin 3 (NT3)
polyethylene glycol (PEG)
biodegradable nanoparticles
ocular neurodegeneration
protein corona
Online Access:https://www.mdpi.com/1999-4923/15/9/2236

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https://www.mdpi.com/1999-4923/15/9/2236

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