HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells

HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells

HPS1, a BLOC-3 subunit that acts as a guanine nucleotide exchange factor of Rab32/38, may play a role in the removal of VAMP7 during the maturation of large dense core vesicles of Paneth cells. Loss of HPS1 impairs lysozyme secretion and alters the composition of intestinal microbiota, which may exp...

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Bibliographic Details
Main Authors: Jiaying Yu, Xin He, Aihua Wei, Teng Liu, Qin Zhang, Ying Pan, Zhenhua Hao, Lin Yang, Yefeng Yuan, Zhao Zhang, Chang Zhang, Chanjuan Hao, Zhihua Liu, Wei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
Hermansky-Pudlak syndrome
HPS1
large dense core vesicle
Paneth cell
inflammatory bowel disease
VAMP7
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.560110/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.560110/full

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