HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells

HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells

HPS1, a BLOC-3 subunit that acts as a guanine nucleotide exchange factor of Rab32/38, may play a role in the removal of VAMP7 during the maturation of large dense core vesicles of Paneth cells. Loss of HPS1 impairs lysozyme secretion and alters the composition of intestinal microbiota, which may exp...

Full description

Bibliographic Details
Main Authors:	Jiaying Yu, Xin He, Aihua Wei, Teng Liu, Qin Zhang, Ying Pan, Zhenhua Hao, Lin Yang, Yefeng Yuan, Zhao Zhang, Chang Zhang, Chanjuan Hao, Zhihua Liu, Wei Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-11-01
Series:	Frontiers in Immunology
Subjects:	Hermansky-Pudlak syndrome HPS1 large dense core vesicle Paneth cell inflammatory bowel disease VAMP7
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.560110/full

Similar Items

Hermansky-Pudlak Syndrome: Identification of Novel Variants in the Genes HPS3, HPS5, and DTNBP1 (HPS-7)
by: Doris Boeckelmann, et al.
Published: (2022-01-01)

A Case Report of Hermansky-Pudlak Syndrome
by: KH Khashei Varnamkhasti, et al.
Published: (2021-04-01)

Oculocutaneous albinism and bleeding diathesis due to a novel deletion in the HPS3 gene
by: Dina Marek-Yagel, et al.
Published: (2022-08-01)

Case Report : Hermansky Pudlak Syndrome (Presenting as late onset heavy Menstrual Bleeding)
by: Amita Ray, et al.
Published: (2013-09-01)

Report of Hermansky–Pudlak Syndrome in Two Families with Novel Variants in <em>HPS3</em> and <em>HPS4</em> Genes
by: Qaiser Zaman, et al.
Published: (2023-01-01)

Novel variant in HPS3 gene in a patient with Hermansky Pudlak syndrome (HPS) type 3
by: Anna Lecchi, et al.
Published: (2020-10-01)

A new case with Hermansky-Pudlak syndrome type 9, a rare cause of syndromic albinism with severe defect of platelets dense bodies
by: Vincent Michaud, et al.
Published: (2021-04-01)

Novel genetic variant of HPS1 gene in Hermansky-Pudlak syndrome with fulminant progression of pulmonary fibrosis: a case report
by: Martina Doubková, et al.
Published: (2019-10-01)

Sequence-Based Mapping and Genome Editing Reveal Mutations in Stickleback Hps5 Cause Oculocutaneous Albinism and the casper Phenotype
by: James C. Hart, et al.
Published: (2017-09-01)

Amelanotic melanoma in a patient with Hermansky-Pudlak syndrome
by: Ryan Fan, BA, et al.
Published: (2022-09-01)

Two Novel Homozygous <i>HPS6</i> Mutations (Double Mutant) Identified by Whole-Exome Sequencing in a Saudi Consanguineous Family Suspected for Oculocutaneous Albinism
by: Sajjad Karim, et al.
Published: (2021-12-01)

Genetic variants associated with Hermansky-Pudlak syndrome
by: Melissa A. Merideth, et al.
Published: (2020-05-01)

Hermansky-Pudlak syndrome; a Case Report
by: Abbas Bagheri, et al.
Published: (2010-01-01)

Clinical Features and Novel Genetic Variants Associated with Hermansky-Pudlak Syndrome
by: Chonglin Chen, et al.
Published: (2022-07-01)

A Novel Likely Pathogenic Variant in the <i>BLOC1S5</i> Gene Associated with Hermansky-Pudlak Syndrome Type 11 and an Overview of Human BLOC-1 Deficiencies
by: Doris Boeckelmann, et al.
Published: (2021-10-01)

Black kidney in Albinism
by: Mohammad-Reza Ardalan
Published: (2014-04-01)

Hermansky-Pudlak syndrome
by: Prabodh Panchadhyayee, et al.
Published: (2014-01-01)

Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome
by: Ross Summer, et al.
Published: (2019-07-01)

Zebrafish Syndromic Albinism Models as Tools for Understanding and Treating Pigment Cell Disease in Humans
by: Sam J. Neuffer, et al.
Published: (2022-03-01)

Hermansky-Pudlak syndrome type 2: A rare cause of severe periodontitis in adolescents—A case study
by: Jun Chen, et al.
Published: (2022-07-01)

Storage pool diseases illuminate platelet dense granule biogenesis
by: Andrea L. Ambrosio, et al.
Published: (2017-02-01)

HERMANSKY-PUDLAK SYNDROME AND GRANULOMATOUS BOWEL INFLAMMATION – REVIEW ARTICLE AND CASE REPORT
by: Urška Berden, et al.
Published: (2022-11-01)

Dermatologic manifestations in patients with the Hermansky–Pudlak syndrome types 1 and 3
by: Gabriel Santos Malave, et al.
Published: (2022-07-01)

Dysregulated myosin in Hermansky-Pudlak syndrome lung fibroblasts is associated with increased cell motility
by: Jewel Imani, et al.
Published: (2022-06-01)

Hermansky-Pudlak syndrome-associated pneumothorax with rapid progression of respiratory failure: a case report
by: Yukari Kato, et al.
Published: (2020-10-01)

Paneth Cells during Viral Infection and Pathogenesis
by: Mayumi K. Holly, et al.
Published: (2018-04-01)

The Immunome in Two Inherited Forms of Pulmonary Fibrosis
by: Souheil El-Chemaly, et al.
Published: (2018-01-01)

Hermansky-Pudlak syndrome: A case report
by: R Vani, et al.
Published: (2014-01-01)

Hermansky-Pudlak syndrome type 2 manifests with fibrosing lung disease early in childhood
by: Meike Hengst, et al.
Published: (2018-03-01)

Development of the software “Water and energy balances calculations for Angara and Yenisei series of HPS”
by: S. S. Trufakin, et al.
Published: (2017-12-01)

Automated Digital Quantification of Pulmonary Fibrosis in Human Histopathology Specimens
by: Lauren C. Testa, et al.
Published: (2021-06-01)

Metaplastic Paneth Cells in Extra-Intestinal Mucosal Niche Indicate a Link to Microbiome and Inflammation
by: Rajbir Singh, et al.
Published: (2020-03-01)

Paneth Cell-Like Component in Prostate Cancer - Case Report
by: Bernardica Jurić, et al.
Published: (2018-01-01)

In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis
by: Elias C. Padilha, et al.
Published: (2023-12-01)

Infantile-onset inflammatory bowel disease in a patient with Hermansky-Pudlak syndrome: a case report
by: Jun Ishihara, et al.
Published: (2019-01-01)

Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant lung surfactant homeostasis in Ruby rats
by: Kazuhiro Osanai, et al.
Published: (2017-04-01)

Necessity Of ABG Analysis In HPS
by: Kalantari M, et al.
Published: (2005-06-01)

Hermansky Pudlak Syndrome Associated Pulmonary Fibrosis
by: Navakumar Manickam, et al.
Published: (2022-01-01)

Case series on silvery hair syndromes: Single center experience
by: Sirisharani Siddiahgari, et al.
Published: (2022-01-01)

Paneth Cell Carcinoma of the Stomach
by: Jun Wan Kim, et al.
Published: (2022-07-01)