Endomorphin-2 Inhibits the Activity of the Spinoparabrachial Projection Neuron through Presynaptic Mechanisms in the Spinal Dorsal Horn in Rats

Endomorphin-2 Inhibits the Activity of the Spinoparabrachial Projection Neuron through Presynaptic Mechanisms in the Spinal Dorsal Horn in Rats

Background/Aims: Spinal dorsal horn (SDH) is one of the most important regions for analgesia produced by endomorphin-2 (EM2), which has a higher affinity and specificity for the µ-opioid receptor (MOR) than morphine. Many studies have focused on substantia gelatinosa (SG, lamina II) neurons to eluci...

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Bibliographic Details
Main Authors: Jun-Bin Yin, Ya-Cheng Lu, Ban Feng, Zhen-Yu Wu, Ying-Biao Chen, Ting Zhang, Zhen-Zhen Kou, Ming-Ming Zhang, Han Zhang, Jin-Lian Li, Hui Li, Tao Chen, Yu-Lin Dong, Yun-Qing Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-03-01
Series:Neurosignals
Subjects:
Endomorphin
Spinal dorsal horn
Parabrachial nucleus
Projection neuron
Presynaptic effect
Rat
Online Access:https://www.karger.com/Article/FullText/488275

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https://www.karger.com/Article/FullText/488275

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