Dissecting intratumoral myeloid cell plasticity by single cell RNA‐seq

Dissecting intratumoral myeloid cell plasticity by single cell RNA‐seq

Abstract Tumor‐infiltrating myeloid cells are the most abundant leukocyte population within tumors. Molecular cues from the tumor microenvironment promote the differentiation of immature myeloid cells toward an immunosuppressive phenotype. However, the in situ dynamics of the transcriptional reprogr...

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Bibliographic Details
Main Authors: Qianqian Song, Gregory A. Hawkins, Leonard Wudel, Ping‐Chieh Chou, Elizabeth Forbes, Ashok K. Pullikuth, Liang Liu, Guangxu Jin, Lou Craddock, Umit Topaloglu, Gregory Kucera, Stacey O’Neill, Edward A. Levine, Peiqing Sun, Kounosuke Watabe, Yong Lu, Martha A. Alexander‐Miller, Boris Pasche, Lance D. Miller, Wei Zhang
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Cancer Medicine
Subjects:
intercellular interaction
monocyte‐to‐M2 differentiation
non‐small cell lung cancer (NSCLC)
single‐cell RNA sequencing (scRNA‐seq)
trajectory analysis
Online Access:https://doi.org/10.1002/cam4.2113

Internet

https://doi.org/10.1002/cam4.2113

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