Computational Simulation of Adapter Length-Dependent LASSO Probe Capture Efficiency

Computational Simulation of Adapter Length-Dependent LASSO Probe Capture Efficiency

Multiplexed cloning of long DNA sequences is a valuable technique in many biotechnology applications, such as long-read genome sequencing and the creation of open reading frame (ORF) libraries. Long-adapter single-stranded oligonucleotide (LASSO) probes have shown promise as a tool to clone long DNA...

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Bibliographic Details
Main Authors: Jingqian Liu, Syukri Shukor, Shuxiang Li, Alfred Tamayo, Lorenzo Tosi, Benjamin Larman, Vikas Nanda, Wilma K. Olson, Biju Parekkadan
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Biomolecules
Subjects:
gene-capture probe
LASSO probe
oxDNA
VMMC simulation
DNA–DNA interaction
Online Access:https://www.mdpi.com/2218-273X/9/5/199

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https://www.mdpi.com/2218-273X/9/5/199

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