Efficacy of PBTZ169 and pretomanid against Mycobacterium avium, Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum in BALB/c mice models

Efficacy of PBTZ169 and pretomanid against Mycobacterium avium, Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum in BALB/c mice models

ObjectivesWe aimed to evaluate the activity of PBTZ169 and pretomanid against non-tuberculous mycobacteriosis (NTM) in vitro and in vivo.MethodsThe minimum inhibitory concentrations (MICs) of 11 antibiotics, against slow-growing mycobacteria (SGMs) and rapid-growing mycobacteria (RGMs) were tested u...

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Bibliographic Details
Main Authors: Luyao Zheng, Xueting Qi, Weiyan Zhang, Hong Wang, Lei Fu, Bin Wang, Xi Chen, Xiaoyou Chen, Yu Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
non-tuberculous mycobacteria
pretomanid
PBTZ169
murine model
BALB/c mice
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1115530/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1115530/full

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