Second generation androgen receptor antagonists and challenges in prostate cancer treatment

Abstract Prostate cancer is a hormone-dependent malignancy, whose onset and progression are closely related to the activity of the androgen receptor (AR) signaling pathway. Due to this critical role of AR signaling in driving prostate cancer, therapy targeting the AR pathway has been the mainstay st...

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Bibliographic Details
Main Authors: Yanhua Chen, Qianqian Zhou, William Hankey, Xiaosheng Fang, Fuwen Yuan
Format: Article
Language:English
Published: Nature Publishing Group 2022-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05084-1