Lanatoside C decelerates proliferation and induces apoptosis through inhibition of STAT3 and ROS-mediated mitochondrial membrane potential transformation in cholangiocarcinoma

Lanatoside C decelerates proliferation and induces apoptosis through inhibition of STAT3 and ROS-mediated mitochondrial membrane potential transformation in cholangiocarcinoma

Introduction: The incidence of cholangiocarcinoma (CCA) has increased worldwide in recent years. Given the poor prognosis associated with the current management approach of CCA, new therapeutic agents are warranted to improve the prognosis of this patient population.Methods: In this study, we extrac...

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Main Authors: Chao Zhang, Hong-Ying Yang, Long Gao, Ming-Zhen Bai, Wen-Kang Fu, Chong-Fei Huang, Ning-Ning Mi, Hai-Dong Ma, Ya-Wen Lu, Ning-Zu Jiang, Liang Tian, Teng Cai, Yan-Yan Lin, Xing-Xing Zheng, Kun Gao, Jian-Jun Chen, Wen-Bo Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
Lanatoside C
cholangiocarcinoma
reactive oxygen species
mitochondrial membrane potential
stat3
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1098915/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1098915/full

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