Gene Expression Analyses in Models of Rosiglitazone-Induced Physiological and Pathological Mineralization Identify Novel Targets to Improve Bone and Vascular Health

Gene Expression Analyses in Models of Rosiglitazone-Induced Physiological and Pathological Mineralization Identify Novel Targets to Improve Bone and Vascular Health

Clinical studies revealed detrimental skeletal and vascular effects of the insulin sensitizer rosiglitazone. We have shown earlier that rosiglitazone accelerates osteoblast differentiation from human mesenchymal stem cells (hMSC) at the expense of increased oxidative stress and cell death. In calcif...

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Bibliographic Details
Main Authors: Claudia Bruedigam, Johannes P. T. M. van Leeuwen, Jeroen van de Peppel
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
osteoblasts
mesenchymal stem cells
vascular smooth muscle
rosiglitazone
PPAR-gamma
vascular calcification
Online Access:https://www.mdpi.com/2073-4409/12/20/2462

Internet

https://www.mdpi.com/2073-4409/12/20/2462

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