Betulinic Acid Alleviates Spleen Oxidative Damage Induced by Acute Intraperitoneal Exposure to T-2 Toxin by Activating Nrf2 and Inhibiting MAPK Signaling Pathways

Betulinic Acid Alleviates Spleen Oxidative Damage Induced by Acute Intraperitoneal Exposure to T-2 Toxin by Activating Nrf2 and Inhibiting MAPK Signaling Pathways

T-2 toxin, which is mainly produced by specific strains of <i>Fusarium</i> in nature, can induce immunotoxicity and oxidative stress, resulting in immune organ dysfunction and apoptosis. Betulinic acid (BA), a pentacyclic triterpenoids from nature plants, has been demonstrated to possess...

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Bibliographic Details
Main Authors: Li Kong, Lijuan Zhu, Xianglian Yi, You Huang, Haoqiang Zhao, Yazhi Chen, Zhihang Yuan, Lixin Wen, Jing Wu, Jine Yi
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Antioxidants
Subjects:
betulinic acid
T-2 toxin
oxidative stress
MAPK signaling pathway
Nrf2 signaling pathway
Online Access:https://www.mdpi.com/2076-3921/10/2/158

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https://www.mdpi.com/2076-3921/10/2/158

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