The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

Most cases of colorectal cancer are linked to mutational inactivation of the Adenomatous polyposis coli (APC) tumour suppressor. APC downregulates Wnt signalling by enabling Axin to promote the degradation of the Wnt signalling effector β-catenin (Armadillo in flies). This depends on Axin's DIX...

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Bibliographic Details
Main Authors: Carolina Mendoza-Topaz, Juliusz Mieszczanek, Mariann Bienz
Format: Article
Language:English
Published: The Royal Society 2011-01-01
Series:Open Biology
Subjects:
apc tumour suppressor
axin degradasome
dishevelled signalosome
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.110013

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https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.110013

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