Effects of a plant cyclotide on conformational dynamics and destabilization of β-amyloid fibrils through molecular dynamics simulations

Effects of a plant cyclotide on conformational dynamics and destabilization of β-amyloid fibrils through molecular dynamics simulations

Aggregation of β-amyloid (Aβ) peptide is one of the hallmarks of Alzheimer’s disease (AD) which results in chronic and progressive neurodegeneration of the brain. A recent study by our group have shown the ability of cyclic disulfide-rich peptides (“cyclotides”) isolated from a medicinal plant, Clit...

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Bibliographic Details
Main Authors: Neha V. Kalmankar, Bhuvaneshwari Rajendrakumar Gehi, Ramanathan Sowdhamini
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
β-amyloid (Aβ) peptide
disulfide-rich peptides
molecular dynamics (MD) simulation
cyclotides
peptide inhibitors
protein -peptide docking
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.986704/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.986704/full

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