Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer’s disease

Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer’s disease

Alzheimer's disease (AD) has become a major public health problem that affects the elderly population. Therapeutic compounds with curative effects are not available due to the complex pathogenesis of AD. Daphnetin, a natural coumarin derivative and inhibitor of various kinases, has anti-inflamm...

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Bibliographic Details
Main Authors: Peipei Gao, Zhen Wang, Mengyao Lei, Jiaxing Che, Shuangxi Zhang, Tiantian Zhang, Yachong Hu, Le Shi, Li Cui, Jiankang Liu, Mami Noda, Yunhua Peng, Jiangang Long
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Pharmacological Research
Subjects:
AD
Daphnetin
Astrocyte
Aβ
GFAP
p-STAT3
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822001724

Internet

http://www.sciencedirect.com/science/article/pii/S1043661822001724

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