Organotypic hippocampal culture model reveals differential responses to highly similar Zika virus isolates

Organotypic hippocampal culture model reveals differential responses to highly similar Zika virus isolates

Abstract Introduction Zika virus (ZIKV) caused an outbreak in Brazil, in 2015, being associated to microcephaly. ZIKV has a strong neurotropism leading to death of infected cells in different brain regions, including the hippocampus, a major site for neurogenesis. The neuronal populations of the bra...

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Bibliographic Details
Main Authors: Marina da Silva Oliveira, Larissa Marcely Gomes Cassiano, Jeanne Pioline, Ketyllen Reis Andrade de Carvalho, Anna Christina de Matos Salim, Pedro Augusto Alves, Gabriel da Rocha Fernandes, Alexandre de Magalhães Vieira Machado, Roney Santos Coimbra
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Neuroinflammation
Subjects:
Zika virus
Organotypic hippocampal culture
Neurodegeneration
Neuroinflammation
Transcriptome
Chromatin remodeling
Online Access:https://doi.org/10.1186/s12974-023-02826-6

Internet

https://doi.org/10.1186/s12974-023-02826-6

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