Antioxidant Compound, Oxyresveratrol, Inhibits APP Production through the AMPK/ULK1/mTOR-Mediated Autophagy Pathway in Mouse Cortical Astrocytes

Antioxidant Compound, Oxyresveratrol, Inhibits APP Production through the AMPK/ULK1/mTOR-Mediated Autophagy Pathway in Mouse Cortical Astrocytes

Oxyresveratrol (OxyR), a well-known polyphenolic phytoalexin, possesses a wide range of pharmacological and biological properties, comprising antioxidant, anti-inflammatory, free radical scavenging, anti-cancer, and neuroprotective activities. Autophagy is a cellular self-degradation system that rem...

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Bibliographic Details
Main Authors: Md. Ataur Rahman, Yoonjeong Cho, Ghilsoo Nam, Hyewhon Rhim
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
oxyresveratrol
amyloid precursor protein (APP)
AMPK-ULK1
mTOR
LC3 puncta
autophagy
Online Access:https://www.mdpi.com/2076-3921/10/3/408

Internet

https://www.mdpi.com/2076-3921/10/3/408

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