Lack of Cannabinoid Receptor Type-1 Leads to Enhanced Age-Related Neuronal Loss in the Locus Coeruleus

Lack of Cannabinoid Receptor Type-1 Leads to Enhanced Age-Related Neuronal Loss in the Locus Coeruleus

Our laboratory and others have previously shown that cannabinoid receptor type-1 (CB1r) activity is neuroprotective and a modulator of brain ageing; a genetic disruption of CB1r signaling accelerates brain ageing, whereas the pharmacological stimulation of CB1r activity had the opposite effect. In t...

Full description

Bibliographic Details
Main Authors: Alessandra Gargano, Eva Beins, Andreas Zimmer, Andras Bilkei-Gorzo
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
endocannabinoid system
stereological counting
noradrenergic neurons
ageing
Online Access:https://www.mdpi.com/1422-0067/22/1/5

Internet

https://www.mdpi.com/1422-0067/22/1/5

Similar Items