Elucidation of the mechanism of action of ailanthone in the treatment of colorectal cancer: integration of network pharmacology, bioinformatics analysis and experimental validation

Elucidation of the mechanism of action of ailanthone in the treatment of colorectal cancer: integration of network pharmacology, bioinformatics analysis and experimental validation

Background: Ailanthone, a small compound derived from the bark of Ailanthus altissima (Mill.) Swingle, has several anti-tumour properties. However, the activity and mechanism of ailanthone in colorectal cancer (CRC) remain to be investigated. This study aims to comprehensively investigate the mechan...

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Bibliographic Details
Main Authors: Shanbo Ma, Xiaodi Guo, Ruisi Han, Qian Meng, Yan Zhang, Wei Quan, Shan Miao, Zhao Yang, Xiaopeng Shi, Siwang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pharmacology
Subjects:
ailanthone
colorectal cancer
network pharmacology
bioinformatic
PI3K/AKT
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1355644/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1355644/full

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