A Brønsted Acid-Catalyzed Multicomponent Reaction for the Synthesis of Highly Functionalized γ-Lactam Derivatives

A Brønsted Acid-Catalyzed Multicomponent Reaction for the Synthesis of Highly Functionalized γ-Lactam Derivatives

Brønsted acids catalyze a multicomponent reaction of benzaldehyde with amines and diethyl acetylenedicarboxylate to afford highly functionalized γ-lactam derivatives. The reaction consists of a Mannich reaction of an enamine to an imine, both generated in situ, promoted by a phosph...

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Bibliographic Details
Main Authors: Xabier del Corte, Edorta Martinez de Marigorta, Francisco Palacios, Javier Vicario
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
γ-lactam
pyrrolidones
multicomponent reactions
organocatalysis
Online Access:https://www.mdpi.com/1420-3049/24/16/2951

Internet

https://www.mdpi.com/1420-3049/24/16/2951

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