Artificial intelligence-based HDX (AI-HDX) prediction reveals fundamental characteristics to protein dynamics: Mechanisms on SARS-CoV-2 immune escape

Summary: Three-dimensional structure and dynamics are essential for protein function. Advancements in hydrogen-deuterium exchange (HDX) techniques enable probing protein dynamic information in physiologically relevant conditions. HDX-coupled mass spectrometry (HDX-MS) has been broadly applied in pha...

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Bibliographic Details
Main Authors: Jiali Yu, Ugur Uzuner, Bin Long, Zachary Wang, Joshua S. Yuan, Susie Y. Dai
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223003590