Chromodomain helicase DNA-binding domain 2 maintains spermatogonial self-renewal by promoting chromatin accessibility and mRNA stability

Chromodomain helicase DNA-binding domain 2 maintains spermatogonial self-renewal by promoting chromatin accessibility and mRNA stability

Summary: Chromodomain helicase DNA-binding domain 2 (CHD2) is a chromatin remodeling factor involved in many developmental processes. However, its role in male germ cell development has not been elucidated. Here, we confirm that CHD2 expression is enriched in the male germline. In a heterozygous kno...

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Bibliographic Details
Main Authors: Ziqian Min, Huan Xin, Xiaowen Liu, Jingyu Wan, Ziling Fan, Xinxu Rao, Jiahui Fan, Lifang Yang, Dan Li
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:iScience
Subjects:
Biological sciences
molecular mechanism of gene regulation
cell biology
transcriptomics
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Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222018247

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http://www.sciencedirect.com/science/article/pii/S2589004222018247

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