Target toxicity design for phase I dose-finding
We propose a new two-/three-stage dose-finding design called Target Toxicity (TT) for phase I clinical trials, where we link the decision rules in the dose-finding process with the conclusions from a hypothesis test. The power to detect excessive toxicity is also given. This solves the problem of wh...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-04-01
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| Series: | Statistical Theory and Related Fields |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/24754269.2020.1800331 |