Mitigation of Glucolipotoxicity-Induced Apoptosis, Mitochondrial Dysfunction, and Metabolic Stress by <i>N</i>-Acetyl Cysteine in Pancreatic β-Cells

Mitigation of Glucolipotoxicity-Induced Apoptosis, Mitochondrial Dysfunction, and Metabolic Stress by <i>N</i>-Acetyl Cysteine in Pancreatic β-Cells

Glucolipotoxicity caused by hyperglycemia and hyperlipidemia are the common features of diabetes-induced complications. Metabolic adaptation, particularly in energy metabolism; mitochondrial dysfunction; and increased inflammatory and oxidative stress responses are considered to be the main characte...

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Bibliographic Details
Main Authors: Arwa Alnahdi, Annie John, Haider Raza
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Biomolecules
Subjects:
glucolipotoxicity
palmitic acid
rin-5f cells
mitochondrial dysfunction
autophagy
apoptosis
Online Access:https://www.mdpi.com/2218-273X/10/2/239

Internet

https://www.mdpi.com/2218-273X/10/2/239

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