A Prebiotic Ribosylation of Pyrimidine Nucleobases Enabled by Metal Cations and Clay Minerals

A Prebiotic Ribosylation of Pyrimidine Nucleobases Enabled by Metal Cations and Clay Minerals

We report a prebiotically relevant solution to the <i>N</i>1-ribosylation of pyrimidine nucleobases, a well-known challenge to the RNA world hypothesis. We found that the presence of metal cations and clay minerals enable the previously unachievable direct ribosylation of uracil. Spectro...

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Bibliographic Details
Main Authors: Qian-Qian Chen, Ze-Run Zhao, Xiao Wang
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Life
Subjects:
origins of life
RNA world
uracil
ribosylation
metal cation
clay mineral
Online Access:https://www.mdpi.com/2075-1729/11/12/1381

Internet

https://www.mdpi.com/2075-1729/11/12/1381

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