Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer

Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer

Abstract Background Adrenocortical cancer (ACC) is a rare and aggressive cancer with dismal 5-year survival due to a lack of effective treatments. We aimed to identify a new effective combination of drugs and investigated their synergistic efficacy in ACC preclinical models. Methods A quantitative h...

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Bibliographic Details
Main Authors: Dipranjan Laha, Robert R.C. Grant, Prachi Mishra, Myriem Boufraqech, Min Shen, Ya-Qin Zhang, Matthew D. Hall, Martha Quezado, Michelly Sampaio De Melo, Jaydira Del Rivero, Martha Zeiger, Naris Nilubol
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Adrenocortical cancer
Maternal embryonic leucine zipper kinase
Cyclin-dependent kinase
β-catenin
Quantitative high-throughput screening
Targeted therapy
Online Access:https://doi.org/10.1186/s13046-022-02464-5

Internet

https://doi.org/10.1186/s13046-022-02464-5

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