Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice

Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice

Alzheimer’s disease (AD) poses a significant threat to the global elderly population. Traditional Chinese medicine (TCM) has been widely utilized in the treatment of AD. Osthole, a bioactive ingredient classified as an “emperor” in many TCM formulas, has been demonstrated to effectively alleviate AD...

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Bibliographic Details
Main Authors: Fanchang Wu, Mingjun Huang, Xue Zuo, Ruiye Xie, Jinman Liu, Junyu Ke, Weirong Li, Qi Wang, Yong Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
osthole
borneol
intranasal administration
bioavailability
APP/PS1 mice
thermosensitive gel
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1224856/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1224856/full

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