Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in MiceSummary

Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in MiceSummary

Background & Aims: We previously showed that histamine suppressed inflammation-associated colonic tumorigenesis through histamine type 2 receptor (H2R) signaling in mice. This study aimed to precisely elucidate the downstream effects of H2R activation in innate immune cells. Methods: Analyse...

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Bibliographic Details
Main Authors: Zhongcheng Shi, PhD, Yuko Mori-Akiyama, MD, Wa Du, PhD, Robert Fultz, PhD, Yanling Zhao, PhD, Wenly Ruan, MD, Susan Venable, Melinda A. Engevik, PhD, James Versalovic, MD, PhD
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Histamine
Cimetidine
Inflammation
Colorectal Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X2100237X

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X2100237X

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