Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination

Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination

Tumor immune escape is a critical problem which frequently accounts for the failure of therapeutic tumor vaccines. Among the most potent suppressors of tumor immunity are myeloid derived suppressor cells (MDSCs). MDSCs can be targeted by all-trans-retinoic-acid (atRA), which reduced their numbers an...

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Bibliographic Details
Main Authors: Annkristin Heine, Chrystel Flores, Heidrun Gevensleben, Linda Diehl, Mathias Heikenwalder, Marc Ringelhan, Klaus-Peter Janssen, Ulrich Nitsche, Natalio Garbi, Peter Brossart, Percy A. Knolle, Christian Kurts, Bastian Höchst
Format: Article
Language:English
Published: Taylor & Francis Group 2017-08-01
Series:OncoImmunology
Subjects:
atra
immunotherapy
mdscs
therapeutical vaccination
tumor immune escape
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1338995

Internet

http://dx.doi.org/10.1080/2162402X.2017.1338995

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