The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy

The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy

Abstract Background Standard neuropathologic analysis of Alzheimer’s brain relies on traditional fluorescence microscopy, which suffers from limited spatial resolution due to light diffraction. As a result, it fails to reveal intricate details of amyloid plaques. While electron microscopy (EM) offer...

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Bibliographic Details
Main Authors: Björn Johansson, Sho Oasa, Aida Muntsant Soria, Ann Tiiman, Linda Söderberg, Ebba Amandius, Christer Möller, Lars Lannfelt, Lars Terenius, Lydia Giménez-Llort, Vladana Vukojević
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cell & Bioscience
Subjects:
Alzheimer’s disease
Amyloid beta peptide
Amyloid fibrils
Immunohistochemistry
Super-resolution STED microscopy
Next generation drug design
Online Access:https://doi.org/10.1186/s13578-023-01086-4

Internet

https://doi.org/10.1186/s13578-023-01086-4

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