Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A

Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A

Abstract The normally antiviral enzyme APOBEC3A is an endogenous mutagen in human cancer. Its single-stranded DNA C-to-U editing activity results in multiple mutagenic outcomes including signature single-base substitution mutations (isolated and clustered), DNA breakage, and larger-scale chromosomal...

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Bibliographic Details
Main Authors: Stefan Harjes, Harikrishnan M. Kurup, Amanda E. Rieffer, Maitsetseg Bayarjargal, Jana Filitcheva, Yongdong Su, Tracy K. Hale, Vyacheslav V. Filichev, Elena Harjes, Reuben S. Harris, Geoffrey B. Jameson
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42174-w

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https://doi.org/10.1038/s41467-023-42174-w

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