METTL3‐stabilized super enhancers‐lncRNA SUCLG2‐AS1 mediates the formation of a long‐range chromatin loop between enhancers and promoters of SOX2 in metastasis and radiosensitivity of nasopharyngeal carcinoma

METTL3‐stabilized super enhancers‐lncRNA SUCLG2‐AS1 mediates the formation of a long‐range chromatin loop between enhancers and promoters of SOX2 in metastasis and radiosensitivity of nasopharyngeal carcinoma

Abstract Background Super enhancers (SE) play pivotal roles in cell identity and diseases occur including tumorigenesis. The depletion of SE‐associated lncRNA transcripts, also known as super‐lncRNA, causes the activity of SE to be dysregulated. Methods We screened and identified an elevated metasta...

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Bibliographic Details
Main Authors: Xinyu Hu, Jianfeng Wu, Yong Feng, Hongxia Ma, Erbao Zhang, Chang Zhang, Qi Sun, Tingting Wang, Yizhi Ge, Dan Zong, Wei Chen, Xia He
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Clinical and Translational Medicine
Subjects:
nasopharyngeal carcinoma
radiosensitivity
SOX2
SUCLG2‐AS1
super‐enhancer
Online Access:https://doi.org/10.1002/ctm2.1361

Internet

https://doi.org/10.1002/ctm2.1361

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