Effect of miR-204&211 and RUNX2 control on the fate of human mesenchymal stromal cells

Effect of miR-204&211 and RUNX2 control on the fate of human mesenchymal stromal cells

MiR-204 and 211 enforced expression in murine mesenchymal stromal cells (MSCs) has been shown to induce adipogenesis and impair osteogenesis, through RUNX2 down-modulation. This mechanism has been suggested to play a role in osteoporosis associated with obesity. However, two further fundamental MSC...

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Bibliographic Details
Main Authors: Sacchetti Benedetto, Fatica Alessandro, Sorci Melissa, Sorrentino Antonio, Signore Michele, Cerio Annamaria, Felicetti Federica, Feo Alessandra De, Pelosi Elvira, Caré Alessandra, Pescarmona Edoardo, Gordeladze Jan Oxholm, Valtieri Mauro
Format: Article
Language:English
Published: EDP Sciences 2017-01-01
Series:Regenerative Medicine Research
Subjects:
Mesenchymal stromal cells
miR-204&
RUNX2
cartilage
hematopoietic support activity
osteogenesis
adipogenesis
Online Access:https://doi.org/10.1051/rmr/170004

Internet

https://doi.org/10.1051/rmr/170004

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