Quercetin Attenuates Diabetic Peripheral Neuropathy by Correcting Mitochondrial Abnormality via Activation of AMPK/PGC-1α Pathway in vivo and in vitro

Quercetin Attenuates Diabetic Peripheral Neuropathy by Correcting Mitochondrial Abnormality via Activation of AMPK/PGC-1α Pathway in vivo and in vitro

The AMPK/PGC-1α pathway-mediated mitochondrial dysfunction has been supposed to play a crucial role in pathogenesis of diabetic peripheral neuropathy (DPN). The present study investigated the neuroprotective potential of quercetin, a natural AMPK activator. Streptozotocin (STZ)-induced diabetic rats...

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Bibliographic Details
Main Authors: Qian Zhang, Wei Song, Bingjia Zhao, Jun Xie, Qing Sun, Xiaohu Shi, Bin Yan, Guoqing Tian, Xiaochun Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neuroscience
Subjects:
diabetes
diabetic peripheral neuropathy
quercetin
AMPK
PGC-1 alpha
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.636172/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.636172/full

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