Tunable control of CAR T cell activity through tetracycline mediated disruption of protein–protein interaction

Tunable control of CAR T cell activity through tetracycline mediated disruption of protein–protein interaction

Abstract Chimeric antigen receptor (CAR) T cells are a promising form of cancer immunotherapy, although they are often associated with severe toxicities. Here, we present a split-CAR design incorporating separate antigen recognition and intracellular signaling domains. These exploit the binding betw...

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Bibliographic Details
Main Authors: Alastair Hotblack, Evangelia K. Kokalaki, Morgan J. Palton, Gordon Weng-Kit Cheung, Iwan P. Williams, Somayya Manzoor, Thomas I. Grothier, Alice Piapi, Valeria Fiaccadori, Patrycja Wawrzyniecka, Harriet A. Roddy, Giulia Agliardi, Claire Roddie, Shimobi Onuoha, Simon Thomas, Shaun Cordoba, Martin Pule
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-01418-9

Internet

https://doi.org/10.1038/s41598-021-01418-9

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