The Role of <i>TP53</i> Mutations in <i>EGFR</i>-Mutated Non-Small-Cell Lung Cancer: Clinical Significance and Implications for Therapy

The Role of <i>TP53</i> Mutations in <i>EGFR</i>-Mutated Non-Small-Cell Lung Cancer: Clinical Significance and Implications for Therapy

Non-Small-Cell Lung Cancer (NSCLC) is the primary cause of cancer-related death worldwide. Oncogene-addicted patients usually benefit from targeted therapy, but primary and acquired resistance mechanisms inevitably occur. Tumor protein 53 (<i>TP53</i>) gene is the most frequently mutated...

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Bibliographic Details
Main Authors: Matteo Canale, Kalliopi Andrikou, Ilaria Priano, Paola Cravero, Luigi Pasini, Milena Urbini, Angelo Delmonte, Lucio Crinò, Giuseppe Bronte, Paola Ulivi
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
Non-Small-Cell Lung Cancer (NSCLC)
Epidermal Growth Factor Receptor (<i>EGFR</i>)
Tumor protein 53 (<i>TP53</i>)
targeted therapy
resistance mechanisms
Online Access:https://www.mdpi.com/2072-6694/14/5/1143

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https://www.mdpi.com/2072-6694/14/5/1143

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