Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation

Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation

<p>Abstract</p> <p>Background</p> <p>Kainic acid (KA)-induced status epilepticus (SE) was involved with release of free radicals. Sesamin is a well-known antioxidant from sesame seeds and it scavenges free radicals in several brain injury models. However the neuroprotec...

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Bibliographic Details
Main Authors: Lin Ching-Huei, Shen Mei-Lin, Peng Yu-Fen, Wu Szu-Pei, Yao Pei-Wun, Hou Chien-Wei, Hsieh Peiyuan F, Chao Ya-Yun, Chang Ming-Hong, Jeng Kee-Ching
Format: Article
Language:English
Published: BMC 2011-05-01
Series:Journal of Neuroinflammation
Subjects:
Status epilepticus
PC12 cells
BV-2 cells
sesamin
kainic acid
reactive oxygen species
thiobarbituric acid reactive substances
nitric acid
superoxide dismutase
mitogen-activated protein kinases
COX-2
Online Access:http://www.jneuroinflammation.com/content/8/1/57

Internet

http://www.jneuroinflammation.com/content/8/1/57

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