Anti-apoptotic and antioxidant mechanisms may underlie the abrogative potential of Ocimum gratissimum Linn. Leaf extract and fractions against trastuzumab-induced cardiotoxicity in Wistar rats

Anti-apoptotic and antioxidant mechanisms may underlie the abrogative potential of Ocimum gratissimum Linn. Leaf extract and fractions against trastuzumab-induced cardiotoxicity in Wistar rats

Clinical use of trastuzumab (TZM), has been widely associated with increased incidence of cardiotoxicity. Ocimum gratissimum Linn. is a household medicinal plant popularly used for treating inflammatory conditions. In this study, we investigated the abrogative potential of 100 mg/kg/day of the ethan...

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Bibliographic Details
Main Authors: Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Abayomi Mayowa Ajayi, Olubunmi Atolani, Sunday Sokunle Soyemi, Alban Ikenna Mgbehoma, Ralph Muehl Albrecht
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Toxicology Reports
Subjects:
Wistar rats
Ocimum gratissimum Linn.
Ethanol leaf extract and solvent fractions
Oxidative stress markers
Apoptosis markers
Trastuzumab-induced cardiotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750024000106

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http://www.sciencedirect.com/science/article/pii/S2214750024000106

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