Preponderance of the oncogenic V599E and V599K mutations in <it>B-raf </it>kinase domain is enhanced in melanoma cutaneous/subcutaneous metastases
<p>Abstract</p> <p>Background</p> <p>Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of mutations within the kinase domain including the activ...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-06-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/5/58 |