Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids

Summary: Amino acids are required for cell growth and proliferation, but it remains unclear when and how amino acid availability impinges on the proliferation-quiescence decision. Here, we used time-lapse microscopy and single-cell tracking of cyclin-dependent kinase 2 (CDK2) activity to assess the...

Full description

Bibliographic Details
Main Authors: Yao Rong, Alicia M. Darnell, Kiera M. Sapp, Matthew G. Vander Heiden, Sabrina L. Spencer
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015516