Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids
Summary: Amino acids are required for cell growth and proliferation, but it remains unclear when and how amino acid availability impinges on the proliferation-quiescence decision. Here, we used time-lapse microscopy and single-cell tracking of cyclin-dependent kinase 2 (CDK2) activity to assess the...
Main Authors: | Yao Rong, Alicia M. Darnell, Kiera M. Sapp, Matthew G. Vander Heiden, Sabrina L. Spencer |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-12-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723015516 |
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