Mutation of the enterohemorrhagic Escherichia coli core LPS biosynthesis enzyme RfaD confers hypersusceptibility to host intestinal innate immunity in vivo

Mutation of the enterohemorrhagic Escherichia coli core LPS biosynthesis enzyme RfaD confers hypersusceptibility to host intestinal innate immunity in vivo

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is an important foodborne pathogen causing severe diseases in humans worldwide. Currently, there is no specific treatment available for EHEC infection and the use of conventional antibiotics is contraindicated. Therefore, identification of potential...

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Bibliographic Details
Main Authors: Cheng-Ju Kuo, Jenn-Wei Chen, Hao-Chieh Chiu, Ching-Hao Teng, Tai-I Hsu, Pei-Jung Lu, Wan-Jr Syu, Sin-Tian Wang, Ting-Chen Chou, Chang-Shi Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Caenorhabditis elegans
lipopolysaccharide (LPS)
Antimicrobial peptides (AMPs)
Enterohemorrhagic Escherichia coli (EHEC)
Intestinal innate immunity
RfaD/GmhD/WaaD
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00082/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00082/full

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