Synthesis, characterization, and pharmacological evaluation of some metal complexes of quercetin as P-gp inhibitors

Synthesis, characterization, and pharmacological evaluation of some metal complexes of quercetin as P-gp inhibitors

Abstract Background Six different metal complexes of quercetin (Cu, Zn, Co, Vd, Mo, Ni) were synthesized, purified, and characterized by their physical and spectral (UV, IR) data. They were evaluated for their P-gp (permeability glycoprotein) inhibitory activity by in vitro everted sac method in rat...

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Bibliographic Details
Main Authors: Kirankumar Shastrala, Sirisha Kalam, Kumaraswamy Damerakonda, Sharvana Bhava Bandaru Sheshagiri, Hitesh Kumar, Ramu Guda, Mamatha Kasula, Satish Kumar Bedada
Format: Article
Language:English
Published: SpringerOpen 2021-05-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Quercetin
Metal complexes
Atorvastatin
P-gp
Inhibitors
P-glycoprotein
Online Access:https://doi.org/10.1186/s43094-021-00252-0

Internet

https://doi.org/10.1186/s43094-021-00252-0

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