Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis

Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis

Matrix remodeling is a salient feature of idiopathic pulmonary fibrosis (IPF). Targeting cells driving matrix remodeling could be a promising avenue for IPF treatment. Analysis of transcriptomic database identified the mesenchymal transcription factor PRRX1 as upregulated in IPF. PRRX1, strongly exp...

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Bibliographic Details
Main Authors: Emmeline Marchal-Duval, Méline Homps-Legrand, Antoine Froidure, Madeleine Jaillet, Mada Ghanem, Deneuville Lou, Aurélien Justet, Arnaud Maurac, Aurelie Vadel, Emilie Fortas, Aurelie Cazes, Audrey Joannes, Laura Giersh, Herve Mal, Pierre Mordant, Tristan Piolot, Marin Truchin, Carine M Mounier, Ksenija Schirduan, Martina Korfei, Andreas Gunther, Bernard Mari, Frank Jaschinski, Bruno Crestani, Arnaud A Mailleux
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
fibrosis
lung
fibroblasts
transcription factors
TGF beta pathway
Online Access:https://elifesciences.org/articles/79840

Internet

https://elifesciences.org/articles/79840

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