OptMAVEn-2.0: De novo Design of Variable Antibody Regions Against Targeted Antigen Epitopes

Monoclonal antibodies are becoming increasingly important therapeutic agents for the treatment of cancers, infectious diseases, and autoimmune disorders. However, laboratory-based methods of developing therapeutic monoclonal antibodies (e.g., immunized mice, hybridomas, and phage display) are time-c...

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Bibliographic Details
Main Authors: Ratul Chowdhury, Matthew F. Allan, Costas D. Maranas
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Antibodies
Subjects:
Online Access:http://www.mdpi.com/2073-4468/7/3/23