mRNA Therapeutic Vaccine for Hepatitis B Demonstrates Immunogenicity and Efficacy in the AAV-HBV Mouse Model

mRNA Therapeutic Vaccine for Hepatitis B Demonstrates Immunogenicity and Efficacy in the AAV-HBV Mouse Model

Chronic infection with hepatitis B virus (HBV) develops in millions of patients per year, despite the availability of effective prophylactic vaccines. Patients who resolve acute HBV infection develop HBV-specific polyfunctional T cells accompanied by neutralizing antibodies, while in patients with c...

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Bibliographic Details
Main Authors: Dorien De Pooter, Wim Pierson, Soheil Pourshahian, Koen Dockx, Ben De Clerck, Isabel Najera, Heather Davis, Ellen Van Gulck, Daniel Boden
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Vaccines
Subjects:
chronic hepatitis B
therapeutic vaccination
mRNA vaccine
lipid nanoparticles
AAV-HBV mice
HBsAg reduction
Online Access:https://www.mdpi.com/2076-393X/12/3/237

Internet

https://www.mdpi.com/2076-393X/12/3/237

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