Role of Acidic Residues in Helices TH8–TH9 in Membrane Interactions of the Diphtheria Toxin T Domain

Role of Acidic Residues in Helices TH8–TH9 in Membrane Interactions of the Diphtheria Toxin T Domain

The pH-triggered membrane insertion of the diphtheria toxin translocation domain (T domain) results in transferring the catalytic domain into the cytosol, which is relevant to potential biomedical applications as a cargo-delivery system. Protonation of residues is suggested to play a key role in the...

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Bibliographic Details
Main Authors: Chiranjib Ghatak, Mykola V. Rodnin, Mauricio Vargas-Uribe, Andrew J. McCluskey, Jose C. Flores-Canales, Maria Kurnikova, Alexey S. Ladokhin
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Toxins
Subjects:
pH-trigger
conformational switching
membrane insertion
Online Access:http://www.mdpi.com/2072-6651/7/4/1303

Internet

http://www.mdpi.com/2072-6651/7/4/1303

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