Bank vole prion protein extends the use of RT-QuIC assays to detect prions in a range of inherited prion diseases

Bank vole prion protein extends the use of RT-QuIC assays to detect prions in a range of inherited prion diseases

Abstract The cerebrospinal fluid (CSF) real-time quaking-induced conversion assay (RT-QuIC) is an ultrasensitive prion amyloid seeding assay for diagnosis of sporadic Creutzfeldt–Jakob disease (CJD) but several prion strains remain unexplored or resistant to conversion with commonly used recombinant...

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Bibliographic Details
Main Authors: Tze How Mok, Akin Nihat, Connie Luk, Danielle Sequeira, Mark Batchelor, Simon Mead, John Collinge, Graham S. Jackson
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-84527-9

Internet

https://doi.org/10.1038/s41598-021-84527-9

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