Slit2/Robo1 signaling inhibits small‐cell lung cancer by targeting β‐catenin signaling in tumor cells and macrophages

Slit2/Robo1 signaling inhibits small‐cell lung cancer by targeting β‐catenin signaling in tumor cells and macrophages

Small‐cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with poor patient prognosis. However, the mechanisms that regulate SCLC progression and metastasis remain undefined. Here, we show that the expression of the slit guidance ligand 2 (SLIT2) tumor suppressor gene is r...

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Bibliographic Details
Main Authors: Dinesh K. Ahirwar, Bo Peng, Manish Charan, Swati Misri, Sanjay Mishra, Kirti Kaul, Salha Sassi, Venkat Sundar Gadepalli, Jalal Siddiqui, Wayne O. Miles, Ramesh K. Ganju
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Molecular Oncology
Subjects:
MDSCs
Robo1
Slit2
small‐cell lung cancer
TAMs
Online Access:https://doi.org/10.1002/1878-0261.13289

Internet

https://doi.org/10.1002/1878-0261.13289

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